![]() He started a non-profit foundation called the Clock Foundation, “because I wanted to insure rigor. “Let’s say a medical doctor orders an epigenetic clock test, and it indicates a patient is older than they should be, what should the doctor say? There’s no cure they can prescribe,” beyond repeating conventional health advice. “Currently these clocks are not useful for the average person because we don’t have an intervention to slow ageing,” he said. Horvath has mixed feelings about the tests’ popularity. But in most states, you can order a biological age test online as long as you’re over 18 and have a credit card. I tried to buy a biological age test from Thorne, but found out that I wasn’t allowed to order one due to laws in New York, which is among a handful of US states that restrict or prohibit “direct access” medical tests. None of these tests have been approved by the FDA. There are popular but less expensive options that don’t use epigenetic clocks, such as Thorne’s biological age test, which costs $99 and requires a trip to a third-party lab to give a blood sample. “Breakthroughs in ageing research are no longer a myth of science fiction but scientific fact,” the company’s website boasts.Ī company called MyDNAge, which claims to offer the “most accurate and reliable DNA Age test”, charges $299 for a blood or urine test that uses a licensed version of Horvath’s clock. They range in price and testing format: Elysium’s $499 saliva test is based on a biological clock developed by Horvath’s former postdoc, Dr Morgan Levine. These biological age tests are marketed as premium wellness products, often with sleek websites, minimalist packaging and influencer endorsements on social media.Įlysium Health’s Index test. In recent years, these methods have led to an explosion in startups that aim to measure biological age for consumers. If that all sounds complex, it’s perhaps crystalized by the name Horvath gave his second-generation clock: GrimAge, as in the Grim Reaper. That data helps the clocks to identify unhealthy ageing with greater precision – and, Horvath suggests, “predict time to death”. Since then, Horvath and other scientists have developed more accurate clocks, based on data collected from the blood samples of the same group of people over many decades. The result was a formula able to estimate age across a human’s entire life course, from fetus to old age. Horvath’s clock tracks several hundreds of these locations. It’s really millions of locations of DNA,” he said. “As we age, certain parts of the DNA gain methylation and other parts lose methylation. Horvath compared methylation to sand moving through an hourglass. In 2011, Horvath found patterns of DNA methylation could be used to accurately estimate human age. Horvath’s clock analyzes certain chemical changes to genetic material, a process called DNA methylation. Epigenetics is the study of how your environment changes the way your genes work. Horvath’s approach, called the “ epigenetic clock”, is considered by many scientists to be the gold standard. Some approaches even claim to determine mortality risk by scanning people’s eyes. Other approaches take blood samples and measure the presence of molecules that correlate with decreased bodily function. One approach focuses on the length of telomeres, which are protective structures on the ends of our chromosomes, that shorten every time a chromosome replicates – making them an approximate yardstick for biological ageing. Chronological age versus biological age how to#“Researchers debate how to define it,” said Horvath. But the first step is to try to measure it, and that’s not straightforward. The hope is that understanding biological age can lead to new life-lengthening interventions. It is in some ways a tautology: if it wasn’t better, we wouldn’t call it biological age.” “Knowing how fast she is really ageing, it gives her a renewed sense of self and how she should live in the upcoming decade.”ĭr Steve Horvath, a 54-year-old UCLA professor who pioneered the first “clock” to indicate human ageing by examining chemical changes to DNA, told me that “biological age is a better predictor of morbidity risk than chronological age. “It was such a relief for her, because it gives her a newfound hope about life planning,” Chan said. “She looks like a 40-year-old!” he said.Ībout two months later, they got the results back: Ivy’s biological age was 43. But with her youthful looks, she still felt healthy. “She always talked about entering her 60s and how it’s a big step, and this is the start of fading away,” Chan told me. Chan felt his mother, Ivy, who is 59 years old, would benefit from knowing her biological age because she was anxious about getting older. ![]()
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![]() And none of these songs have a danceable beat or that bracing Bee Gees falsetto. Now known as the Brothers Gibb - with Barry writing songs - they attracted the attention of a local DJ, and eventually. The quiet and contemplative "How Can You Mend a Broken Heart" even hit No. Jones)," "I've Gotta Get a Message to You," "(The Lights Went Out in) Massachusetts," "To Love Somebody," and "I Started a Joke" were all big hits in America. In a word, the Bee Gees were weird, and yet it worked: "New York Mining Disaster 1941 (Have You Seen My Wife, Mr. Sounding less like the Beatles and more like a tightly harmonizing, more vocally accomplished, folk-influenced, gently psychedelic Herman's Hermits who sang long-titled story-songs and melancholic ballads, the Bee Gees scored a number of smashes in the late 1960s and early 1970s. In the mid-'60s, the Gibbs moved to London, hoping to cash in on the British rock craze of the era. The group already had a long, active, and healthy career as hitmakers by the time disco hit. Robin sang the melodious chorus while Maurice is barely audible in the song though he is there. The group sang recognisable three-part tight. They had chart topping singles covering a span of 32 years. '/> twice concert manila 2022 gorou x reader lemon wattpad big old floppy tits. Their last appearance in the charts was 1998. Comment below with facts and trivia about the song and we may include it in our song facts Comments. The trio were especially successful as a popular music act in the late 1960s and early 1970s, and later as prominent performers of the disco music era in the mid-to-late 1970s. You Should Be Dancing was the 20 song in 1976 in the Pop charts. Their lineup consisted of brothers Barry, Robin, and Maurice Gibb. The song, released in 1977, signified the coming of age of Barry, who took the role of lead vocalist. The Bee Gees were a pop music group formed in 1958. But disco was only one thing the Bee Gees could do, and in the waning part of the 1970s, it was simply their latest endeavor. How Deep Is Your Love is one of the most liked Bee Gees songs ever. The Bee Gees may be associated with the shimmering disco grooves and stratospheric falsetto of Saturday Night Fever, but the band scored hits in four decades with substance and style, reinventing themselves through setbacks and comebacks marked by graceful harmonies and impeccable songcraft. ![]() ![]() The Battle for Wesnoth is a turn-based tactical strategy game with a high fantasy theme.īuild up a great army, gradually turning raw recruits into hardened veterans. Warlords Battlecry III is poised to receive even greater accolades than the previous award-winning titles in the Warlords Battlecry series. All of these features, coupled with new races and hero classes, new spells and items, and new building and dragons meld to form a Real-Time Strategy game that once again raises the benchmark for other games in the genre. While being a strong RTS outright, there are also numerous activities for players to engage in between battles, such as obtaining titles and awards, trading and purchasing items & retinue members, and even an upgradeable castle to reflect your importance and influence in the world of Etheria.Įxtra features included in Warlords Battlecry III are specifically geared to please the legions of previous Battlecry players, including the removal of hero and unit caps, the addition of new special abilities for high-level heroes and the creation of an intuitive hero system. Warlords Battlecry III continue to perfect its automated feature system, greatly reducing gameplay micromanagement and quickly proving to be the holy grail of RTS games among gamers of the genre. It is a true sequel to Warlords Battlecry I & II, featuring many familiar races and troop-types, while also adding some new ones into the mix. Warlords Battlecry III further expands the Battlecry tradition of featuring persistent RPG-like fantasy heroes with its retinue of loyal followers fighting massive battles in the Warlords' world of Etheria. Persistant game world with continuous, gripping storyline and myriad sub-questsĪwe-inspiring 3D graphics with zoom levels from isometric to 1st-Person-views Was this recommendation.? More than 30 different enemy races, from cowardly goblins to powerful demons and dragonsĪ multitude of spells, divided into different categories of magic (white, black, elemental, etc.) High degree of identification with the hero-avatar, whose skills and strengths can be improved by the playerĬlick’n’Fight: This revolutionary control system guarantees instant action, the best possible overview and completely new tactical possibilities in battleĦ races – Humans, Dwarves, Elves, Dark Elves, Orcs and Trolls – that can be used simultaneously (!) to build settlements and fight battles Innovative game design: The unique mixture of RTS and RPG elements offers a brand new game experience. Soon, the time will come when the power of one may change the destiny of many. A human damned to immortality, bound forever by the power of the blood runes… Now, only a few years after the end of the Convocation, evil is back – stronger and more powerful than ever before – to finish what was started. All that was left were a few islands, connected by magic portals. Huge armies, bound by the the power of ancient runes, brought war and destruction to the lands that survived the initial onslaught. Continents shattered like glass, the pieces strewn about like leaves in the wind. Entire countries were wiped out in the blink of an eye when the devastating power of the Elements was unleashed – Elements summoned by dark rituals. In their immeasurable greed and constant thirst for power, the thirteen most powerful Mages of all time doomed the land, hurling it into an endless spiral of chaos and despair. ![]() ![]() Naturally, the truth is nothing so sentimental. This entity gives Tsukasa several Story Breaker Powers while leaving her motives vague beyond implying that she is, somehow, the ghost of his Missing Mom. hack//SIGN: Early during his imprisonment in The World, Tsukasa is contacted by a mysterious entity whose nature, motives and even physical form are completely unknown, her sole manifestations being only ominous environmental changes and a disembodied female voice. It became stronger by feeding on the data these emotions were attached to and ultimately became addicted to it, creating an empty void from which it tried to devour both worlds as Abaddomon. When the Digital World reached out to humanity as a source of strength to overcome this cycle, Negamon tried to do the same and instead found the Network, which was filled with negative emotions. Negamon from Digimon Adventure: (2020) was originally a secretive entity that spread conflict among Digimon to keep the Digital World's literally endless propensity for life and growth in check.After procuring stray Digimon-data and finding its way into the Digital World the Digimon inhabit, the D-Reaper develops the same Adaptive Ability Digimon have and soon begins evolving into a monstrosity that threatens all worlds. The D-Reaper from Digimon Tamers was originally a data cleanup program made in The '80s that targets and deletes programs that "evolved past parameters".Even if destroyed, his body can release dark spores to contaminate other beings. The Greater-Scope Villain of the first two series, and to a degree, Tamers, Milleniummon is so powerful that his mere existence can twist the space-time around him and his stronger forms can wipe out entire universes by existing alone.The result was a malevolent, continuously digivolving digimon set loose upon the internet, devouring any data is can and eventually hacking various military systems, nearly causing a nuclear apocalypse in less than a day. Diaboromon from Digimon Adventure Movie: Our War Game! and Diablomon's Counterattack was once a Digi-Egg created by Willis on his computer, only to get infected by a computer virus.His existence alone warps the Digiworld and creates multiple disasters and he speaks in a Voice of the Legion and is rather incomprehensible in thought, only ever making it clear that he desires nothing but to make other Digimon suffer the same pain his origins went through. He resembles a cross between all of the series' villains up to that point, with his main body being a gigantic polyhedron with multiple metallic tentacles made of DNA strands with claws on their ends and has a humanoid body that wears a black cape with red trimmings, has a mask-like face with eyes that have exposed muscles around them and what appear to be zippers holding his upper limbs, while his lower half is the rest of the body and is connected through his abdomen being split in multiple tentacles connecting him. One of the first examples comes from Digimon Adventure with its final villain and the overall main antagonist, Apocalymon, an embodiment of the hatred, resentment, and sorrow of countless Digimon that perished trying to achieve Digievolution and subsequently were deleted.It's no exaggeration either, as Guilmon's Mega-evolved form Megidramon was able to tear apart the very fabric of the Digital World by simply existing. Even more so are ones like Guilmon that possess the Digital Hazard symbol, which indicates that they have the potential to become powerful enough to threaten the existence of both the Digital World and the human world. Quite a few Digimon in general, especially those of Ultimate level and beyond fit this trope in regards to their appearances, power, and abilities.It has several powerful forms and wants nothing but the destruction of all reality. It is a virus infecting Yyggdrasil, the heavenly supercomputer that controls reality. The Lord of Terror from Ah! My Goddess. ![]() ![]() ? ATI, NVIDIA or Intel HD Graphics c 512MB VRAM and aboveĪfter installing FxFactory double-click to unpack the files, then double-click on the unzipped package, all established where necessary. #Fxfactory pro 2 how to? 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Would you buy this Yes 1 No 0 Price 360.00 (AUD) FxFactory Pro 2 is a collection of filters, generators and transitions for Apples Final Cut Pro, Motion and Final Cut Express, offering 122 effects, including 52 new plug-ins. ![]() ![]() choose the right piece of sporting equipment (bike, surf or skate board, shoes, protective.arrange flowers for different uses: for the table, as a corsage.make your own jewelry from antique buttons.create a seasonal center piece for the dining table.290 good demonstration speech topics Nature Then go through it assessing the positive as well as negative aspects of each idea, keeping the audience members, your interest, setting, time and assessment needs in mind. Rather than pick the first idea that jumps out, build up a short list. Think of them as beginnings or starting points. Use the demonstration speech ideas below to kick-start your own creativity. How to use these demonstration speech ideas You may find there are restrictions on using varying forms of visual aids: video or power-point for example. if the speech is part of a public speaking course. #Ispeech demo crack how toChoose one or two aspects you know you can cover well in the time you have available.įor instance, how to knit has many elements: how to hold the needles, how to cast stitches on, how to choose the right wool, how to read a knitting pattern, how to do a specific stitch. If you really want to tackle a big topic, and it's a good fit with your audience, if it's possible, break it down. What you select needs to fit easily into the allotted time limit. There is no point in choosing something complex with a large number of steps to show and teach if you don't have the time to cover them. The time you've got to prepare the speechĭoes the topic you're considering need a long time to prepare thoroughly? Are there visual aids you need to make to accompany it? How much research do you need to do before you can begin to prepare the speech? 5. Where is the speech to be given? In a classroom? In a public hall? In a living room? In the open air?ĭoes what you're planning to do fit the venue? 4. What would be of value, and appropriate, for them to know?.If you're thinking about a topic you know they already know well, is there something new you could teach them about it?.What demonstration speech topics would truly interest them?.You need to think about your audience before making your final choice. Ideally when you finish your speech, you'll find yourself on the receiving end of question after question from eager listeners. Without enthusiasm or knowledge it's incredibly hard to inspire others that they want to find out more about a subject. Your choice of demonstrative speech topic needs to be something you are genuinely interested in, and know about or, want to know about. 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ROTATE IMAGE OPENOFFICE SOFTWAREToday, 200 million users worldwide trust its successor LibreOffice, which has been continuously developed under the umbrella of the Open Document Foundation and through the development work of 1000 volunteers and commercial software companies such as Collabora. ROTATE IMAGE OPENOFFICE CODEThe disclosure of the source code of StarOffice in 1999, which in the meantime had grown into a complete suite, enabled the development and rapid distribution of OpenOffice. The code of today’s LibreOffice originated from StarOffice, whose first word processor was already published in the 80s. ROTATE IMAGE OPENOFFICE FREEThe availability of the source code guarantees that free / open source software can continue to develop independently of the commitment or existence of individual economic players. Most importantly it shows that free / open source software won’t just vanish if one stakeholder pulls the plug. The journey from StarOffice to OpenOffice and from there to LibreOffice is quite an interesting piece of history. History shows strength of free / open source software In this blog we put more focus on the history of the story the blog at Collabora, has more focus on the interesting technology.īut before we tell you more about the new app, we show you first what it looks like: There is a lot we want to tell you about this first open source office app for iOS. What started back in around 1992 as the well-known StarOffice, then was and now lives on as LibreOffice, is finally available on every relevant platform including (but not limited to) iOS, iPadOS, MacOS, Android, Chrome OS, Windows, Linux and also within the browser. The efforts for this are led by Adfinis SyGroup and Collabora. There is now a free / open source office suite available on iOS: Collabora Office. What seemed impossible for a long time has now become reality. Collabora Office is now available on iOS. If you do not want your writing to be edited mercilessly and redistributed at will, then do not submit it here.A free / open source office suite within the palms of our hands. Use thereof is explained in our trademark policy (see Project:Copyrights for details). Their respective logos and icons are also subject to international copyright laws. "LibreOffice" and "The Document Foundation" are registered trademarks of their corresponding registered owners or are in actual use as trademarks in one or more countries. ROTATE IMAGE OPENOFFICE LICENSEThis does not include the source code of LibreOffice, which is licensed under the GNU Lesser General Public License ( LGPLv3). Please note that all contributions to The Document Foundation Wiki are considered to be released under the Creative Commons Attribution-ShareAlike 3.0 Unported License, unless otherwise specified.Based on work by Dennis Roczek and Eric Bright and others. This page was last edited 06:39:03, by Raal Raal.insert your newly-rotated image into the document through Insert ▸ Image.make the nesessary changes to the image, e.g.open the image you need to rotate in your default image editor.copy and paste the picture into the Writer document.under Rotation angle, set the rotation angle you want and.insert or copy/paste the picture into the Draw document.create a new Draw document ( File ▸ New ▸ Drawing).once your mouse turned into the arrow, left-click, move your mouse up or down, and release the left-click.Note that your mouse turns into a round, two-headed arrow and move your mouse over one of the red handels around the image (at one of the corners of the image).Note that the green handles around the image turn red click the Rotate icon on the toolbar (a semi-circle arrow).click on your image for the image toolbar to appear ( View ▸ Toolbars ▸ Image). ![]() ![]() The Gaelic Language (Scotland) Act, passed by the Scottish Parliament in 2005, recognised Gaelic as an official language of Scotland and required the creation of a national plan for Gaelic to provide strategic direction for the development of the Gaelic language. Irish and Ulster Scots enjoy limited use alongside English in Northern Ireland, mainly in publicly commissioned translations. In Wales, all pupils at state schools must either be taught through the medium of Welsh or study it as an additional language until age 16, and the Welsh Language Act 1993 and the Government of Wales Act 1998 provide that the Welsh and English languages should be treated equally in the public sector, so far as is reasonable and practicable. Seven other languages are recognised by the British Government under the European Charter for Regional or Minority Languages – Welsh, Scottish Gaelic, Scots, Cornish, Irish, Ulster Scots, and British Sign Language. The Old English heroic poem Beowulf is located in the British Library.įirst spoken in early medieval England, the English language is the de facto official language of the UK, and is spoken monolingually by an estimated 95% of the British population. Since the end of World War II, British culture has accented its contributions to diversity from Afro-Caribs, South Asians and other immigrants. Historically, the British Isles were a culturally grouped country and developed native traditions, however as a result of the expansion of the British Empire, the country absorbed different peoples of the world. 15 Traditional communication and greeting cards.5 National parks, museums, libraries, and galleries.4.1 Robin Hood and the ballad tradition.3.8 Performing arts, carnivals, parades.A global opinion poll for the BBC saw the UK ranked the third most positively viewed nation in the world (behind Germany and Canada) in 20. The UK has been described as a "cultural superpower", and London has been described as a world cultural capital. Sport is an important part of British culture, and numerous sports originated in the country including cricket, football and rugby. British colonies and dominions influenced British culture in turn, particularly British cuisine. A subset of these states form the Anglosphere, and are among Britain's closest allies. As a result of the British Empire significant British influence can be observed in the language, law, culture and institutions of its former colonies, most of which are members of the Commonwealth of Nations. The Industrial Revolution began in the UK and had a profound effect on the family socio-economic and cultural conditions of the world. Britain contains some of the world's oldest universities, has made many contributions to philosophy, science, technology and medicine, and is the birthplace of many prominent scientists and inventions. The UK is also the home of the Church of England, the state church and mother church of the Anglican Communion, the third-largest Christian denomination. Britain has also made notable contributions to music, cinema, art, architecture and television. The modern novel was invented in Britain, and playwrights, poets, and authors are among its most prominent cultural figures. īritish literature is particularly esteemed. Although British culture is a distinct entity, the individual cultures of England, Scotland, Wales and Northern Ireland are diverse and have varying degrees of overlap and distinctiveness. British culture is influenced by the combined nations' history its historically Christian religious life, its interaction with the cultures of Europe, the traditions of England, Wales, Scotland and Ireland and the impact of the British Empire. ![]() ![]() It might also ask you to combine certain items in the scene, like putting eggs into a nest or framing a picture. Besides simply finding a listed item sometimes the word on the list is a clue, such as saying "trunk owner" when you need to find an "elephant". 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